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    Ingredient Science
    7 min read

    Immune Signaling & Cytokines

    Cytokines are the messenger proteins your immune cells use to communicate. This article explains how the balance between alarm and calming signals shapes your overall immune health.

    Curated by the Red Road Wellness Research Team
    Missouri, USAAbout our editorial standards

    Your immune system communicates using tiny messenger proteins called cytokines. Think of them as text messages that immune cells send to each other. These messages tell other cells what to do: 'Come help fight here,' 'Calm down, the threat is handled,' or 'Start repairing this tissue.' There are dozens of different types of these messengers, each with specific instructions.

    Some cytokines are like alarm signals. When your body detects something harmful, certain immune cells release these alarm cytokines to trigger a strong defensive response. They cause inflammation, which is actually your body's way of sending more defenders to the area and making it harder for harmful agents to spread. A fever is one example of this alarm system at work.

    Other cytokines act as calming signals. Once the threat is handled, these messengers tell your immune cells to stand down and start cleanup and repair. Without these calming signals, the inflammatory response would continue unchecked, potentially causing damage to your own tissues.

    Your body works best when these alarm and calming signals are in balance. When you are well-rested, eating well, and managing stress, your body maintains this balance naturally. But chronic stress, poor sleep, and unhealthy habits can tip the balance toward too many alarm signals, leading to a state of ongoing, low-level inflammation that your body never fully resolves.

    The communication system is beautifully designed with backup systems. Multiple messengers can carry similar instructions, so if one pathway is disrupted, others can compensate. However, this also means that when the system gets stuck in an imbalanced state, it can be challenging to reset.

    References & Citations

    1. [1]
      Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007;37(Suppl 1):S34-S45.
    2. [2]
      Turner MD, et al. Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta. 2014;1843(11):2563-2582.
    3. [3]
      Schett G, Neurath MF. Resolution of chronic inflammatory disease: universal and tissue-specific concepts. Nat Commun. 2018;9(1):3261.

    This information is provided for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.

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